FoxO6 regulates Hippo signaling and growth of the craniofacial complex
نویسندگان
چکیده
منابع مشابه
Actin Cytoskeleton Regulates Hippo Signaling
Hippo pathway controls the organ size by modulating cell proliferation and apoptosis. However, the upstream regulation of hippo signaling by actin cytoskeleton is not clear. To elucidate the role of actin as an upstream regulator of Hippo signaling, the levels of F (filamentous)-actin in cells were elevated using jasplakinolide, an actin-stabilizing drug. Induction of F-actin formation in HeLa ...
متن کاملan investigation about the relationship between insurance lines and economic growth; the case study of iran
مطالعات قبلی بازار بیمه را به صورت کلی در نظر می گرفتند اما در این مطالعه صنعت بیمه به عنوان متغیر مستفل به بیمه های زندگی و غیر زندگی شکسته شده و هم چنین بیمه های زندگی به رشته های مختلف بیمه ای که در بازار بیمه ایران سهم قابل توجهی دارند تقسیم میشود. با استفاده از روشهای اقتصاد سنجی داده های برای دوره های 48-89 از مراکز ملی داده جمع آوری شد سپس با تخمین مدل خود بازگشتی برداری همراه با تعدادی ...
15 صفحه اولregulates Hippo signaling by modulating cortical
13 14 The Hippo pathway controls tissue growth through a core kinase cascade that impinges on the 15 transcription of growth-regulatory genes. Understanding how this pathway is regulated in 16 development remains a major challenge. Recent studies suggested that Hippo signaling can be 17 modulated by cytoskeletal tension through a Rok-myosin II pathway. How cytoskeletal tension is 18 regulated o...
متن کاملHippo signaling: growth control and beyond.
The Hippo pathway has emerged as a conserved signaling pathway that is essential for the proper regulation of organ growth in Drosophila and vertebrates. Although the mechanisms of signal transduction of the core kinases Hippo/Mst and Warts/Lats are relatively well understood, less is known about the upstream inputs of the pathway and about the downstream cellular and developmental outputs. Her...
متن کاملFoxO6 regulates memory consolidation and synaptic function.
The FoxO family of transcription factors is known to slow aging downstream from the insulin/IGF (insulin-like growth factor) signaling pathway. The most recently discovered FoxO isoform in mammals, FoxO6, is highly enriched in the adult hippocampus. However, the importance of FoxO factors in cognition is largely unknown. Here we generated mice lacking FoxO6 and found that these mice display nor...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS Genetics
سال: 2018
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1007675